Tottenham Hotspur could be missing three crucial players for the upcoming showdown with West Ham United. Thomas Frank's side travel to the London Stadium on Saturday afternoon and will be aiming to return to winning ways following the defeat to Bournemouth before the international break.
And they might have to do it without a host of key members of their squad. Playmaker James Maddison remains restricted to the side-lines following his long-term knee injury.
Meanwhile, Sweden international Dejan Kulusevski is not expected to return to action any time soon. The pair join young defender Kota Takai in being ruled out.
And while Radu Dragusin remains out of contention for the clash with West Ham at least, Spurs have - however - received positive news regarding his fitness. The defender has returned to training following his cruciate ligament injury.
It might be some time before he returns to the pitch, but to see him back in training is an encouraging sign. Fellow defender Cristian Romero has also given Frank a boost having returned from international duty unscathed.
He was ruled out of Argentina's second game of the window due to suspension, meaning he was eligible to return earlier than expected. Elsewhere, Yves Bissouma and Dominic Solanke could also be back in the fold for Tottenham following their injury issues.
From the West Ham side of things, Graham Potter has far less headaches when it comes to getting an XI together. The Hammers only have three injury doubts ahead of the game at the time of writing.
German forward Niclas Fullkrug is out due to a calf strain. He is expected to be recovering for a fortnight.
Meanwhile, George Earthy could potentially return to contention after recovering from an ankle problem. Brazilian winger Luis Guilherme is also a doubt having picked up a collarbone issue during pre-season.
West Ham will certainly be keen to have as many players available as possible as Graham Potter's side aim to make it back-to-back Premier League wins. They downed Nottingham Forest 3-0 before the international break to secure their first victory of the campaign.
Spurs, in the meantime, are aiming to return to winning ways following their defeat at the hands of Bournemouth earlier this month.
Following the clash with West Ham, Spurs get their Champions League campaign underway having been drawn to take on Villarreal in their opening game.