The Africa Cup of Nations kicks off earlier than usual this year - with up to 17 Premier League clubs set to be affected by players jetting off to host country Morocco.
The tournament runs from 21 December until 18 January.
There has been no official announcement about which date clubs will have to release their players by - and it could vary depending on agreements.
Players could miss up to six, or in some cases seven, Premier League matches - plus FA Cup and Carabao Cup games - if they reach the final.
The group stages end on 31 December, so quickly eliminated players may only miss half that amount.
Arsenal, Chelsea and Leeds do not have any players due to play in the 2025 Afcon - with Sunderland and Wolves losing the most players.
BBC Sport looks at which teams are due to lose players.
The biggest blow for Crystal Palace will be the loss of Senegal winger Ismaila Sarr, who has scored eight goals in all competitions this season.
Then they have three maybes.
Forward Christantus Uche, who has only featured as a substitute for Palace so far, is a Nigeria international but was not in their most recent squad.
Neither Morocco defender Chadi Riad nor Mali midfielder Cheick Doucoure have played a competitive game of football since January following serious knee injuries.
Whoever does go will miss Palace's Carabao Cup quarter-final with Arsenal on 23 December.
Nottingham Forest have up to four players who will leave for Afcon - but it could be as low as one.
Midfielder Ibrahim Sangare is certain to be in the Ivory Coast squad, while defender Willy Boly will hope to be but has barely played this season - and was not in their most recent squad.
Full-back Ola Aina and forward Taiwo Awoniyi are both Nigeria internationals. But Aina has not played since hamstring surgery in September - and Awoniyi has not been in a squad this year.
Wolves are bottom of the Premier League and without a win - and five players will jet off.
Zimbabwe pair Marshall Munetsi and Tawanda Chirewa, Ivory Coast defender Emmanuel Agbadou, Nigeria striker Tolu Arokodare and Cameroon full-back Jackson Tchatchoua will all be heading off.
Chirewa has not played for Wolves this season, but the rest are all regulars.
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