Atlético Madrid have only won one of their last 10 UEFA Champions League meetings with English clubs (D2 L7), beating Manchester United 1-0 in March 2022.
Tottenham Hotspur have faced Atlético Madrid just once before in European competition, beating them in the 1963 Cup Winners' Cup final 5-1.
Atlético Madrid have progressed from two of their three previous UEFA Champions League last 16 ties against English clubs, beating Liverpool in 2019-20 and Manchester United in 2021-22, losing the other to Chelsea in 2020-21.
Tottenham have only lost one of their last five UEFA Champions League meetings with Spanish opponents (W2 D2), a 2-4 home defeat to Barcelona in the 2018-19 group stage.
Atlético Madrid have never lost a UEFA Champions League knockout stage game under Diego Simeone at either their former home, the Vicente Calderón (W7 D4), or their current home, the Riyadh Air Metropolitano (W6 D2).
Tottenham have won their last three UEFA Champions League games without conceding a goal (v Slavia Prague, Borussia Dortmund and Eintracht Frankfurt). They have never previously won four consecutive matches in the European Cup/UEFA Champions League, nor have they kept four straight clean sheets before.
This will be Tottenham boss Igor Tudorâs first game as a manager in the knockout stages of the UEFA Champions League, while he has won just two of nine matches in the competition overall (D2 L5). His most recent game in the competition was a defeat in the Spanish capital, losing 0-1 at Real Madrid in charge of Juventus this season (October 2025).
Ademola Lookman has had a hand in 16 goals in his last 21 appearances in major European competition (12 goals, 4 assists), while he scored in his only start in the UEFA Champions League to date for current club Atlético Madrid (v Club Brugge in the previous round).
Randal Kolo Muani has been directly involved in five goals in seven games for Tottenham in the UEFA Champions League this season (3 goals, 2 assists), already his most in a single edition. Indeed, only two players have netted more than three goals in their first Champions League campaign as a Spurs player: Gareth Bale and Peter Crouch (both 4 in 2010-11).
Along with leading his team for goal involvements (7 â 5 goals, 2 assists), Atlético Madrid forward Julián Ãlvarez has averaged 71.1 high-intensity pressures per 90 in the UEFA Champions League; the highest average of any player remaining in the 2025-26 tournament (min. 300 minutes played).