Here’s all you need to know...
What time does the match start?
Kick-off is at 5.30pm BST on Saturday.
How can I watch the game?
Saturday’s match will be televised live in the UK on Sky Sports Premier League and Sky Sports Main Event.
As always, supporters can also keep fully up-to-date with all the action via live text and audio commentary during the game on our Match Centre.
Video highlights will be posted on official club channels from two hours after the final whistle, while a full match replay will be available to watch on SPURSPLAY from midnight after the game.
What is the team news?
Rodrigo Bentancur remains out as he serves the second game of his three-match suspension following his dismissal at Old Trafford earlier this month.
Roberto De Zerbi will update the media on Friday lunchtime with the rest of our team news.
Who is the referee?
Chris Kavanagh is set to referee the game at Stamford Bridge on Saturday, assisted by Dan Cook and Ian Hussin.
Farai Hallam will be the fourth official, with John Brooks and assistant Richard West on VAR duties.
Which kits will the teams be wearing?
Chelsea will be in their familiar blue shirts, blue shorts and white socks with their goalkeeper in orange.
We’ll be wearing our Lilywhite home shirts with navy blue shorts, but will change to navy blue socks as usual at Stamford Bridge in order to avoid a colour clash.
What will the weather be like?
Heavy rain is forecast for Saturday. Temperatures should be around 13 degrees during the game.
What is the latest travel information?