After a 1-1 draw with Twente in midweek, the boss has once again made alterations to her starting line-up. Hannah Hampton returns in goal for this Women's Super League fixture, while defender Nathalie Bjorn makes her 50th appearance for Chelsea.
Captain Millie Bright also passes a huge milestone, making her 300th appearance for the Blues as she lines up alongside Bjorn in defence.
Quartet Keira Walsh, Erin Cuthbert, Johanna Rytting Kaneryd and Wieke Kaptein come back into the starting XI to face Spurs.
Niamh Charles makes her return from injury and goes straight into the side, while Lucy Bronze is also named on the bench for the first time this season following her post-European Championship lay-off.
Chelsea: Hampton, Carpenter, Bjorn, Bright (c), Charles, Walsh, Cuthbert, Thompson, Kaptein, Rytting Kaneryd, Beever-Jones