Cristian Romero is expected to be out for six weeks, according to a report in Argentina.
Tottenham were dealt another huge blow when Romero was forced off in the early stages during the 4-3 defeat to Chelsea on Sunday. He looked to play on for a few minutes before signalling to the bench to be substituted.
It has been the second successive season that Romero has been unable to play through a home game with Chelsea after being substituted last year. Speaking after the game, Ange Postecoglou revealed the centre-back had 'felt his quad' during the game.
"Romero is just obviously hugely disappointing," Postecoglou said. "He felt something in his quad. He trained really well. He wasn't the one I was worried about, to be honest, but it's just the way the season's going for us unfortunately. So we just have to wait and see."
Here, football.london has taken a look at the latest injury update surrounding Romero.
Injury update
According to TyC Sports journalist Gaston Edul, the Argentina international will be sidelined for six weeks after suffering a muscular injury. Initial suggestions that it could have been another foot injury was ruled out by Postecoglou.
"It's a totally different injury, but also people I'm sure are aware of our situation," the Spurs boss said. "It's not like I've got a multitude of options there, so, you know, you've got to make these decisions.
"Both players trained and tried well, and they both wanted to help. So you make these decisions with all the best information. Like I said, it's not like Romero re-injured his toe, it's a totally different injury, which could happen at any time."
Possible return date
A six-week absence could see Romero only come back to action in mid-January. As a result, he could potentially miss nine games until then.
Tottenham's upcoming games
Rangers (A) - Europa League - Thursday, December 12.
Southampton (A) - Premier League - Sunday, December 15.
Manchester United (H) - EFL Cup quarter-final - Thursday, December 19.
Liverpool (H) - Premier League - Sunday, December 22.
Nottingham Forest (A) - Premier League - Thursday, December 26.
Wolves (H) - Premier League - Sunday, December 29.
Newcastle (H) - Premier League - Saturday, January 4.
Tamworth (A) - FA Cup - Sunday, January 12.
Arsenal (A) - Premier League - Wednesday, January 15.
Romero's setback comes a major blow for Tottenham as injuries have continued to be a problem this season.
Injuries piling on
Brennan Johnson and Micky van de Ven were also substituted off in the game against Chelsea. "Brennan just didn't feel well. He didn't feel well at half-time, but he wanted to give it a go, but he just wasn't feeling 100 per cent, so I had to take him off," Postecoglou explained.
"And then, well, the plan was always for Micky to play 60, 70 [minutes] today. Obviously, I thought Romero would be okay to play 90, but Mickey, probably 60,70. So we were always going take him off. He didn't feel anything significant. He just felt tightness, but we were always going to take him off anyway."
Guglielmo Vicario (ankle), Richarlison (thigh), Rodrigo Bentancur (suspended), Yves Bissouma (suspended), Mickey Moore (illness), Ben Davies (thigh) and Wilson Odobert (thigh) are all unavailable.