Crystal Palace manager Oliver Glasner has named four changes following the Eagles' Carabao Cup quarter-final loss to Arsenal on Tuesday.
Dean Henderson returns in goal, while Nathaniel Clyne, Will Hughes and Justin Devenny are also given starts.
Eddie Nketiah, Jaydee Canvot and Walter Benitez drop to the bench, while Chris Richards misses out through injury.
Crystal Palace XI: Henderson, Clyne, Lacroix, Guehi, Mitchell, Lerma, Hughes, Wharton, Devenny, Pino, Mateta.
Subs: Benitez, Nketiah, Uche, Esse, Canvot, Sosa, Rodney, Drakes-Thomas, Benamar.
Tottenham boss Thomas Frank names two changes from the team which lost to Liverpool last weekend.
Both are enforced following the red cards for Xavi Simons and Cristian Romero in that match, with Richarlison and Kevin Danso coming in.
Tottenham XI: Vicario, Porro, Danso, Van de Ven, Spence, Gray, Bergvall, Bentancur, Kudus, Richarlison, Kolo Muani.