Eintracht Frankfurt are 33rd in the table and one of only four sides to already be eliminated from the competition.
Their team includes former Leeds defender Robin Koch, Oscar Hojlund, the brother of ex-Manchester United striker Rasmus and Mario Gotze, who scored the winning goal for Germany in the 2014 World Cup final.
Eintracht Frankfurt XI: Santos, Theate, Koch, Amenda, Brown, Larsson, Højlund, Buta, Götze, Skhiri, Knauff.
Subs: Zetterer, Grahl, Chaibi, Kristensen, Dahoud, Bahoya, Doan, Chandler, Collins, Doumbia, Dills, Staff.
Thomas Frank makes five changes from the Tottenham side that drew 2-2 at Burnley, with starts for Destiny Udogie, Archie Gray, Pape Matar Sarr, Joao Palhinha and Randal Kolo Muani.
Dominic Solanke is named among the Spurs substitutes and is the only regular first-teamer among a youthful bench.
Tottenham XI: Vicario, Udogie, Romero, Danso, Gray, Spence, Matar Sarr, Palhinha, Odobert, Simons, Kolo Muani.