The Dane has arrived at Spurs this summer after almost seven years at Brentford in which he established the Bees as a Premier League side.
Now, Frank brings his new team to the Etihad Stadium for a 12:30 (UK) kick-off on Saturday.
Having gone up against Frank on eight occasions before and suffered defeat twice, Guardiola is well aware of his qualities.
Speaking in his pre-match press conference on Friday, Guardiola was full of praise for his opposite number.
“It’s too early to know but I don’t have any doubts that Thomas will do an incredible job like he did at Brentford,” he said.
“He’s a top-class manager in different scenarios with different alternatives in terms of how they can play. We saw it and we suffered it at Brentford.”
Watch the full press conference at the top of the page...
City v spurs app coverage
Our official app allows you to follow all of the action from the Etihad in one place.
Minute-by-minute text updates will begin in our Matchday Centre two hours before kick-off, while our Matchday Live show will begin at around 11:15 (UK).
Steph Houghton and Michael Brown will be the guests on the latest Matchday Live show alongside presenter Cel Spellman, offering their expert insight before, during and after the action.
During the game you can also listen to live audio commentary from Alistair Mann and Andy Morrison while our text commentary continues.
Make sure to have push notifications turned on as well, so you can be alerted to key moments in the action, including goals, red cards and the team news.
We’ll have a quick-hit 2-minute highlights package available at 17:15 (UK), while you can sign-in to watch a free 8-minute edit at midnight. On CITY+ meanwhile, there’ll be our popular full-match replay as well as our new extended highlights offering which features the best 20 minutes of action from the game. Both are also available at midnight.