Andrée Jeglertz’s side were full value for the three points with Aoba Fujino, Vivianne Miedema and Kerstin Casparij all on target in the first 45.
Grace Clinton marked her City debut with a fourth after coming off the bench, before Laura Coombs found the net deep into stoppage time.
MATCH REPORT: Spurs 1-5 CITY
An Olivia Holdt effort to get Spurs on the scoresheet, and fine penalty save from Lize Kop to deny Khadija ‘Bunny’ Shaw, were small blotches on an otherwise excellent night for the Blues.
Spurs came into the tie as the only side yet to concede in the WSL this season, but City cut through the hosts with some fluid, fast-paced football to race into a commanding lead.
And Jeglertz’s side showed no signs of slowing up in the closing stages even with the win all but secured, building on last week’s hard-fought 2-1 win over Brighton.