Mikel Arteta’s side top the Premier League table after 11 games and are unbeaten in 14 across all competitions.
They were pegged back in the last minute by Sunderland in a 2-2 draw last time out, as Brian Brobbey struck in injury time.
Spurs, meanwhile, conceded a stoppage-time equaliser of their own against Manchester United, as Matthijs de Ligt snatched a point for ten-man United at the Tottenham Hotspur Stadium.
Arsenal will be without Gabriel but could welcome back a couple of key players, with Noni Madueke and Gabriel Martinelli both nearing returns.
There are question marks over Viktor Gyokeres and Martin Odegaard, while Riccardo Calafiori is a doubt following the international break.
As for Tottenham, Dominic Solanke’s comeback trail remains slow, while Radu Dragusin and Mohammed Kudus could both be included here.
TV channel: In the UK, the game will be televised live on Sky Sports Main Event and Sky Sports Premier League, with coverage starting at 4pm GMT.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app and website.