On as a first-half substitute with his team already leading 2-0 thanks to Steve Ngoura’s double, Mathys saw team-mate Joane Gadou sent off and the visitors score twice to restore parity.
However, with 14 minutes remaining, he found the net to secure all three points for his nation and send them through to the 2027 tournament as winners of qualifying Group C.
It was his second goal of this international window after he also hit the target in a 1-1 draw with Iceland last week.
Mathys becomes the third Spurs player to secure qualification for the Under-21 Euros in recent days after Mateus Fernandes (Portugal) and Archie Gray (England) did likewise with their countries.
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