Andrews confirmed there are no fresh injury concerns ahead of their second trip to north London in four days.
He refused to confirm if Igor Thiago will return to the starting line-up, after starting on the bench at Arsenal, saying: "I'm not going to tell you the team, but he's clearly in a good place."
On Thiago's Premier League Player of the Month nomination: "He's played very, very well. He's getting this type of recognition with the goal return and the performance levels that he's been producing on a consistent basis."
The Bees made five changes in their defeat at Arsenal and Andrews was asked about squad rotation: "I have zero concern about making changes, it's needed at times because it's a long season."
He added: "You don't achieve anything with 11 players. The feel of the group needs to be fresh. Every player needs to feel involved in the process on a day-to-day basis."
Andrews said his squad are "in a good place" and have coped well "despite the exertions of the last two games over a space of a few days".
On their struggles away from home: "In terms of performances, how close the games have been, we're learning a lot as a group, myself included. With substitutions, the impact that they can have on games is vital - controlling the feel of a stadium and feeding off the opposition crowd."
With Spurs managed by former Brentford boss Thomas Frank, Andrews was asked about his relationship with the Dane: "Thomas is someone I regard as a friend. He's a big part of the reason why I wanted to come to the club. I have a lot of respect for him and what he achieved at this football club. He was a really successful part of the club's history."
On if it will affect his players: "We're not robots. Naturally, there will be emotions of certain levels involved in the game because players had relationships with the staff, but equally we're preparing for a game that we want to absolutely compete in."