Kobbie Mainoo has been ruled out of the trip to north London with a minor knock, and is replaced in the matchday squad by youngster Jack Fletcher.
Meanwhile, Lisandro Martinez, who is back in full training after making a recovery from the ACL injury he suffered in the home loss to Crystal Palace at the beginning of the year, has not travelled with the squad to the capital.
Amorim did not consider the Argentine for selection against Nottingham Forest last weekend, insisting the central defender needed more time before being ready for a return to action.
"He (Martinez) wants to go to this one [Forest], he isn't going to this one,” Amorim told reporters ahead of the game at the City Ground. “He's going to need time. He has started training with us. Slowly he is going to get better.”
Despite a further full week’s worth of training under his belt, Martinez will not make his Man United return until after the international break.
Harry Maguire, however, does start as one of the three central defenders to help combat Tottenham’s set-piece strengths as well as posing a threat of his own in the opposition box.