West Ham in huge trouble
West Ham's defeat at home to Nottingham Forest on Tuesday means they are seven points from safety. Burnley will climb above the Hammers if they return to winning ways against Manchester United.
And Leeds will move 11 points clear of the relegation zone if they win at Newcastle.
Parker needs a win
Burnley v Man Utd (20:15 GMT)
Burnley
Has there been a more dramatic start to a calendar year?
After Enzo Maresca left Chelsea on New Year's Day, Manchester United and Ruben Amorim went their separate ways on Monday.
Will there be more departures over the next few days?
Scott Parker is one boss of several bosses crying out for a win. His Burnley side have not won since October, have lost nine of their last 11, and are hurtling towards relegation. Tonight they host managerless Manchester United.
Will Man City & Villa cut Arsenal's lead?
Arsenal do not play Liverpool until Thursday so a chance for both Manchester City and Aston Villa to move three points behind the leaders.
Chelsea, with new boss Liam Rosenior watching from the stand, will move into the top four with a win at local rivals Fulham.
The winners of Brentford and Sunderland, who meet at the Gtech, could end the night in the top five depending on results elsewhere.
get involved
Get Involved
Click 'Get Involved' at the top of the page
Who will be Manchester United's next permanent boss? Have Chelsea made the right choice in appointing Liam Rosenior as Enzo Maresca's replacement? Are Bournemouth, who are desperate for points, right to start Manchester City-bound Antoine Semenyo tonight? And is Scott Parker skating on thin ice at Burnley?
Please do let us know your views on all the above and much more.
'I hope it's a move that doesn't swallow him up'
Fulham v Chelsea (19:30 GMT)
On BBC Radio 5 Live's Monday Night Club former top flight striker Chris Sutton said the biggest challenge Liam Rosenior will encounter at Chelsea is switching to taking charge of players who have "won World Cups, are worth millions and players who have big egos and back themselves".
"I just hope it's a move which doesn't swallow him up or have a negative effect on his coaching career. I'm not saying it will because he's a super smart guy," he added.
Tonight will tell us a lot about Newcastle
Newcastle United v Leeds United (20:15 GMT)
Ciaran Kelly
BBC Sport reporter at St James' Park
Back-to-back victories has changed the mood at Newcastle United.
But we will know a lot more about this side following the visit of in-form Leeds United to St Jamesâ Park.
Can Newcastle do what Liverpool, Manchester United and Chelsea have all failed to do in recent weeks and defeat Leeds?
They will have to be at their best to do so against a side who travel to St James' with real belief following a seven-game unbeaten run.
Leeds have come away from Anfield, the Stadium of Light and the Gtech Community Stadium with a well-earned point on each occasion in recent weeks.
No wonder, then, manager Daniel Farke vowed âwe wonât make it easyâ for Newcastle.
That is not in doubt.
Team news - Ballard starts for Sunderland
Brentford v Sunderland (19:30 GMT)
Keith Andrews makes two changes to the Brentford side that started their 4-2 victory at Everton on Sunday.
Left-back Rico Henry and winger Keane Lewis-Potter come in with Aaron Hickey and Mikkel Damsgaard dropping to the bench.
Brentford XI: Kelleher, Kayode, Ajer, Collins, Henry, Yarmoliuk, Janelt, Jensen, Lewis-Potter, Schade, Igor Thiago.
Subs: Valdimarsson, Hickey, Van den Berg, Pinnock, Henderson, Nelson, Damsgaard, Peart-Harris, Donovan.
There are also two changes to the Sunderland team from their draw at Tottenham as Dan Ballard returns to the starting XI after injury.
Regis Le Bris also brings Chris Rigg into the line-up with Dennis Cirkin and Eliezer Mayenda among the substitutes.
Sunderland XI: Roefs, Mukiele, Ballard, Alderete, Geertruida, Hume, Xhaka, Le Fee, Adingra, Rigg, Brobbey.
Subs: Patterson, Cirkin, Neil, Mayenda, OâNien, Mundle, Hjelde, Jones, Tutierov.
Team news - Two changes for Palace, Sancho in for Villa
Crystal Palace v Aston Villa (19:30 GMT)
Oliver Glasner is forced into making two changes to the Crystal Palace side that lost to Newcastle on Sunday.
Jefferson Lerma (concussion) and Nathaniel Clyne (adductor) join the club's growing injury list, and are placed by Jaydee Canvot and Justin Devenny.
Chris Richards returns but is only fit enough for the bench.
Crystal Palace XI: Henderson, Canvot, Lacroix, Guehi, Devenny, Wharton, Hughes, Mitchell, Johnson, Pino, Mateta.
Subs: Benitez, Uche, Sosa, Richards, Rodney, King, Benamar, Casey, Drakes-Thomas.
Unai Emery also makes two changes following Aston Villa's defeat of Nottingham Forest at the weekend.
Lucas Digne replaces Ian Maatsen at left-back, while Jadon Sancho starts on the wing in place of Emiliano Buendia.
Aston Villa XI: Martinez, Cash, Konsa, Lindelof, Digne, Kamara, Tielemans, McGinn, Rogers, Sancho, Watkins.
Subs: Bizot, Buendia, Torres, Garcia, Malen, Jimoh-Aloba, Maatsen, Bogarde, Hemmings.
Team news - Everton make one change, Wolves unchanged
Everton v Wolves (19:30 GMT)
Everton boss David Moyes has made one change to the side that were beaten 4-2 by Brentford on Sunday.
Tyler Dibling drops to the bench in place of Harrison Armstrong.
Everton XI: Pickford, O'Brien, Tarkowski, Keane, Mykolenko, Iroegbunam, Armstrong, Garner, McNeil, Grealish, Barry.
Subs: Travers, King, Patterson, Beto, Dibling, Rohl, Aznou, Welch, Campbell.
Rob Edwards has named an unchanged Wolves side after they picked up their first win of the season against West Ham on Saturday.
Wolves XI: Sa, S. Bueno, H. Bueno, Gomes, Arias, Hwang, Arokodare, Mosquera, Mane, Krejci, Tchatchoua.
Subs: Johnstone, Doherty, Andre, Moller Wolfe, Strand Larsen, Lima, Chirewa, Lopez, Ojinnaka.
Team news - Semenyo starts for Bournemouth; Simons returns for Spurs
Bournemouth v Tottenham (19:30 GMT)
Antoine Semenyo starts for Bournemouth in what could be his final game for the Cherries, with the winger expected to complete his Manchester City transfer this week.
Andoni Iraola makes two changes to the side that were beaten 3-2 by Arsenal with Eli Junior Kroupi and Lewis Cook coming in as injured Justin Kluivert and David Brooks drop out.
Bournemouth XI: Petrovic, Truffert, Cook, Senesi, Scott, Evanilson, Tavernier, Jimenez, Kroupi, Hill, Semenyo.
Subs: Forster, Soler, Brooks, Smith, Diakite, Adli, Unal, Milosavljevic, Rees-Dottin.
Mohammed Kudus is out injured for Tottenham but Xavi Simons returns to the starting line-up after a three-match suspension.
It's one of the five changes that Spurs boss Thomas Frank makes as Randal Kolo Muani, Djed Spence, Lucas Bergvall and Joao Palhinha are also back in the starting 11.
Tottenham XI: Vicario, Palhinha, Simons, Tel, Bergvall, Romero, Porro, Spence, Bentancur, Van de Ven, Kolo Muani.
Subs: Kinsky, Dragusin, Danso, Richarlison, Gray, Odobert, Davies, Scarlett, Williams-Barnett.
Team news - Smith Rowe starts for Fulham and Chelsea ring changes
Fulham v Chelsea (19:30 GMT)
Nizaar Kinsella
BBC Sport Chelsea reporter
Fulham make one change from their 2-2 draw against Liverpool on Sunday by bringing in Sander Berge for Sasa Lukic.
Ryan Sessegnon is fit again after a minor hamstring injury and returns to the bench.
Manager Marco Silva continues in his new back five system which has improved the club's fortunes.
Fulham XI: Leno, Diop, Anderson, Cuenca, Castagne, Berge, Cariney, Robinson; Wilson, Smith Rowe; Raul
Subs: Lemcomte, Sessegnon, Amissah, Reed, Lukic, Ridgeon, Adama, Kevin, Kusi-Asare
Chelsea make six changes and welcome back Robert Sanchez, Marc Cucurella and Moises Caicedo from injury and suspension.
The other three changes see Tosin Adarabioyo rotated in against his former club, along with Liam Delap and Andrey Santos coming in.
Previously ill defender Wesley Fofana is back but only makes the bench.
Chelsea XI: Sanchez; Gusto, Chalobah, Tosin, Cucurella; Caicedo, Andrey Santos; Palmer, Fernandez, Neto; Delap
Subs: Jorgensen, Acheampong, James, Fofana, Hato, Estevao, Garnacho, Gittens, Joao Pedro
The cricketer's son recalled by Guardiola - who is Max Alleyne?
Ask Me Anything
Ask Me Anything
Manchester City starting line-up includes debutant Max Alleyne, but who is the defender?
The highly-rated England Under-21 international joined City from Southampton's academy in 2021 for a reported £1.5m fee and is described as a "cultured and ball-playing" centre-back.
The 20-year-old has sporting pedigree running in his family, with his father being former England cricket all-rounder and current Gloucestershire coach Mark Alleyne.
Boss Pep Guardiola recalled the young centre-back from a loan spell at Watford following injuries to Ruben Dias and Josko Gvardiol - with the latter set for surgery after breaking his shinbone.
Read more in our full explainer here
Team news - Alleyne makes debut for Man City, Gross starts for Brighton
Man City v Brighton (19:30 GMT)
Shamoon Hafez
Football news reporter at Etihad Stadium
Manchester City boss Pep Guardiola has shaken up the team tonight, partly because of injuries to give others a rest, following Sunday's late draw against Chelsea.
It means there is a senior City debut for 20-year-old academy product Max Alleyne, who was recalled from a season-long loan at Watford to aid the club's injury crisis in defence.
He partners Abdukhodir Khusanov, with Nathan Ake, Nico Gonzalez and Jeremy Doku also coming in.
Josko Gvardiol, Ruben Dias, Nico O'Reilly, Rodri and Rayan Cherki drop out.
Man City XI: Donnarumma, Nunes, Alleyne, Khusanov, Ake, Gonzalez, Reijnders, Silva, Foden, Doku, Haaland.
Brighton boss Fabian Hurtzeler makes three changes from the side that beat Burnley last time out.
Pascal Gross makes his first start since returning from Borussia Dortmund in this transfer window, with Maxim de Cuyper and Jack Hinshelwood also coming in.
Joel Veltman, Brajan Gruda and Charalampos Kostoulas drop out.
Former City midfielder James Milner, aiming to be only the fifth player aged 40 or over to feature in the Premier League, is on the bench.
Brighton XI: Verbruggen, Gomez, Van Hecke, Dunk, Kadioglu, De Cuyper, Hinshelwood, Ayari, Mitoma, Gross, Rutter.
'For all intents and purposes, he's a Man City player'
Bournemouth v Tottenham (19:30 GMT)
Sami Mokbel
BBC Sport Senior football correspondent on BBC Radio 5 Live
On Antoine Semenyo's future:
He is due to play against Tottenham, that will be his final appearance for Bournemouth. He is then due to travel up to Manchester, all of the arrangements are being made now.
He will have his medical and the likelihood is that there will be an announcement either on Thursday evening, or Friday. Unless there is a wild or unexpected twist, he is for all intents and purposes, a Manchester City player.
Will Chelsea players impress new boss?
Fulham v Chelsea (19:30 GMT)
New Chelsea manager Liam Rosenior will be in the stands at Craven Cottage to watch this game.
He takes charge of training on Thursday and will be in the dugout for Saturday's FA Cup third-round meeting with Charlton Athletic.
Calum McFarlane, the under-21 team's boss, will take interim charge of Chelsea tonight for the second and final time.
Ex-Tottenham and England forward Chivers dies aged 80
Bournemouth v Tottenham (19:30 GMT)
Tottenham Hotspur
Before we get going, there is some really sad news to bring you from Tottenham.
Former Spurs and England forward Martin Chivers has died at the age of 80.
During his eight years in north London, the striker scored 174 goals in 367 outings to help the club win the League Cup twice, as well as the Uefa Cup.
He also scored 14 goals in his 24 appearances for England.
Tottenham said, external: "It is with immense sadness that we announce the passing of our legendary former striker, Martin Chivers.
"We extend our deepest sympathies to Martin's family, friends and former team-mates at this incredibly sad time.
"Rest in peace, Martin. One of the all-time greats."
Read more here.