Mohammed Kudus had a scan on Monday so is expected to be unavailable.
Destiny Udogie "is training and looking better", but Frank could not say for certain whether he will be fit enough for Wednesday's game.
Frank says Dominic Solanke will be back "in the near future", but after six months sidelined "it will take time" for him to get back to his previous level.
On Brennan Johnson's £35m move to Crystal Palace: "There was an opportunity to sell him now and give him the opportunity to try something else, and that was the right decision."
Frank said "it's fair to say we are short of offensive options" so is hopeful to solve that issue in the January transfer window.
He confirmed the club have appealed against Cristian Romero's red card against Brentford.
On opponents Bournemouth: "They're a very good team. I know they haven't won as much lately but they are very competitive. The game against Arsenal [on Saturday] was very tricky and they could have got something out of [it]."