Frank began his news conference by confirming the "positive news" that Cristian Romero, Destiny Udogie, Wilson Odobert are all available to face Chelsea.
However, Dominic Solanke will not return until after the November international break and Dejan Kulusevski is "still not on the grass". Meanwhile, Kota Takai is "about to be training soon" after a quad injury.
On captain Romero: "Very aware of trying to be able to make the best possible decisions. I'll get a lot of the decision from the medical staff but, in the end, it's always on me. If a player breaks down, it's on me. He's ready to be involved tomorrow. Let's see how much."
Frank said facing rivals Chelsea under the lights will be "unique and special": "I'm really looking forward to it. We need the fans behind us. I know they give us everything and the best clubs are all united together. We have maybe the best stadium in the world and definitely the best fans in the world, and we know the sound in that stadium can be insane."
More on the importance of facing the Blues: "There is so much on it against a very good Chelsea team. It has everything to be a top game that will hopefully put you on the edge of your seat."
Reflecting on Wednesday's Carabao Cup defeat at Newcastle, Frank said: "I like to have a challenge. If we had won - which I think we weren't far from - we would be in the next round and still competing. It is tough to compete in 60 games. Every club is rotating. That is part of it and you're trying to find the right balance."
On Micky van de Ven's form, after the defender scored two goals in last weekend's win over Everton: "Every defender needs to be good in defence and attack. He is very good on the ball, has good composure and his pace is quite unique. The cool defending in the decisive moments he is doing better and better. He is ticking a lot of boxes. He just needs to continue to perform at a good level consistently."