Frank confirmed he has no fresh injury concerns with Radu Dragusin not yet fit to start and Cristian Romero unavailable through suspension.
He added that none of his long-term absentees are nearing a return.
On Dominic Solanke and Dejan Kulusevski: "I'd love to have them ready to play for us, but they're unavailable, other players need to step up. It's much easier to say they're in, when available, rather than put a time-frame on it."
However, Randal Kolo Muani is fit to start after scoring his first two goals for the club against parent club Paris St-Germain on Wednesday: "Yeah, he will be fit enough to start against Fulham. I think he performed well, his best performance so far. It was exciting. Now it's about doing it consistently, every game."
Reflecting on the 5-3 defeat in Paris after after Sunday's 4-1 loss against Arsenal, Frank said: "I am pleased with the performance and response we got from the players against PSG. I think the aggression in the high pressure, the forwardness and intensity should have earned us a point or points against PSG but some randomness and game management meant we didn't. That is what we have to learn from."
How does he remain calm under pressure?: "Trust my experience, trust my staff, my players, the club, the leadership - that's key for us to progress as a structure. Just to keep doing that, keep believing, keep working. Always one more conversation, one more video clip, one more meeting, one more training session, constantly try to improve bits, know where you want to go, try to improve the culture, the style of play every single day. That's the key."
On whether teenagers Archie Gray and Lucas Bergvall could start together in the Premier League: "I think if you perform like you did against the European champions away from home, you're ready to start in the Premier League."
Is the visit of Fulham is a must-win game?: "I'm very aware a top performance and a win will be very helpful. I go into every game believing we will win. I need to make sure we're well prepared, to pick the best possible team."