The Tottenham boss brings his side to face Eddie Howe's United in Wednesday night's Carabao Cup tie
Tottenham head coach Thomas Frank admits it is a new challenge dealing with the demands of Champions League and domestic competitions in his first season at the North London club.
The former Brentford boss saw his side move into third in the Premier League table with an impressive 3-0 win over Everton on Sunday - with a Carabao Cup tie against Newcastle United next up on Wednesday night.
Like Eddie Howe's men, Spurs are getting to grips with the busy schedule that eight Champions League fixtures generate and the strains it places on their squads.
Both sides recorded Premier League wins following their European exersions - Newcastle beat Benfica 3-0 on Tuesday night while Spurs were held to a goalless draw by Monaco - with a place in the quarter-finals of the Carabao Cup now up for grabs.
Newcastle hold home advantage as they look to defend the trophy they won at Wembley last March, but while Frank admits he will need to manage his squad carefully, he insists their strong away form is a huge part of their success so far.
"We really are competitive, especially away from home," Frank said following their first visit to Everton's Hill Dickinson Stadium.
"I think it is three years since the club was in the Champions League, so quite an inexperienced squad to go every three or four days.
"It is difficult to compete in both tournaments so to keep the energy and focus, plus we also did it after all the travel, it showed a lot about the mentality."
The Dane's plans are starting to come together at Spurs, although the win at Everton was only the second in their last six games.
"I think we are in the beginning of building something," added Frank.
"I'm very happy with a lot of things: the defensive side, attacking set-pieces - but there is a bit we need to work on offensively to be more free-flowing.
"The clean sheet mentality is a very good foundation to stand on. Who knows where it will lead but I need to take it one game at a time."
On-loan Paris St Germain striker Randal Kolo Muani made his first start for Spurs, playing an hour against Everton, and could again be involved against Newcastle.
"It was pleasing to see his first 60 minutes," Franks said. "He is still building his physicality and sharpness.
"At times he lacks some of the interaction with the front four but that is an ongoing process."