James Maddison is not expected to return from injury this season.
The Tottenham midfielder damaged a knee in the first leg of their Europa League semi-final against Bodo/Glimt.
Ange Postecoglou said after Sunday's 1-1 draw at West Ham that it was 'not looking promising' for Maddison.
Spurs are still running scans on the full extent of the damage, but the 28-year-old England international is unlikely to play again in the three weeks before the end of the season.
It is another injury blow for Postecoglou in a campaign full of them.
For Maddison, personal heartbreak with Tottenham on the brink of the Europa League final.
They are 3-1 up against Bodo/Glimt with the second leg in Norway on Thursday.
The final is in Bilbao in just over a fortnight.
Midfielder Lucas Bergvall suffered an ankle injury on the eve of the first leg which has ruled him out of the rest of the season.
Captain Son Heung-min has missed the last four games with a foot injury. Son has been training alone and is a doubt for the trip to Norway.
Dominic Solanke, also forced off against Bodo/Glimt, missed the draw at West Ham but is confident of being fit for Thursday.