Tottenham will host Manchester City in the standout Carabao Cup fourth round tie.
The last 16 draw took place on Wednesday night following the conclusion of Liverpool and Arsenal's wins over West Ham and Bolton respectively.
Man City progressed thanks to a 2-1 win over Watford on Tuesday night with Jeremy Doku and Matheus Nunes getting the goals to send them through.
Meanwhile, Spurs secured their spot in the fourth round with a 2-1 win over Coventry last week.
Now Premier Legaue champions City and Spurs will meet in north London, with a quarter-final place at stake.
Arsenal, who beat Bolton 5-1 at the Emirates Stadium, will travel to face Preston in the fourth round while Brighton host holders Liverpool at the AMEX Stadium.
Arne Slot's side progressed thanks to a 5-1 victory over West Ham at Anfield with Diogo Jota and Cody Gakpo grabbing two goals each.
Manchester United have been drawn against Leicester City at home following the 7-0 hammering of Barnsley and the Foxes' dramatic penalty shootout win over Walsall.
It was that clash with the League Two side that saw a fan try to confront Steve Cooper before being tackled by a Walsall player.
The winners of AFC Wimbledon and Newcastle will face Chelsea in the next round, with the rearranged third round tie set to take place at St James' Park following the flooded pitch at the Cherry Red Records Stadium.
AFC Wimbledon's vice president Ivor Heller has told talkSPORT the club could spend around £1million on repairing their pitch.
A fan-led JustGiving page has been set up to raise funds to fix the pitch and has already raised £111,000 at the time of writing.
Elsewhere, Aston Villa host Crystal Palace, Southampton welcome Stoke City and Brentford take on Sheffield Wednesday.
talkSPORT co-hosts Jason Cundy and Jamie O'Harahad their say on the Carabao Cup draw, with some fantastic fixtures to look forward to.
Speaking on The Sports Bar, ex-Chelsea defender Cundy said: "There's a couple of tasty ones, Brighton vs Liverpool is a tasty one.
"And obviously your boys [Tottenham] against Man City, that catches the eye.
"Villa vs Palace... you expect Arsenal to go through."
Left dejected by Tottenham's opponents, former Spurs midfielder O'Hara stated: "Is there any danger of us just getting an easy route to a final? Come on."
To which Cundy quipped: "You're never going to win anyway even if you've got an easy route, you'll still lose in the final."
He continued: "You expect Newcastle to beat Wimbledon and that'll be a tough game for Chelsea, it'll be a tough game for both to be honest.
"It's amazing this competition, because you win two games [round three and four] and then you're staring the quarters in the face."
Ties will be played the week commencing October 28th.