The event, "An Evening with Tottenham Legends", will take place at the Cliffs Pavilion on May 13.
It will feature former Spurs stars Glenn Hoddle, Michael Dawson, Gary Mabbutt, Sandro, Aaron Lennon, and Graham Roberts.
Together, the players made more than 2,000 appearances for the club.
The event will give supporters the chance to hear stories about their careers, training ground memories, matches, dressing room life and the managers they worked under.
There will also be an audience question and answer session, allowing fans to put questions directly to the players during the show.
A limited number of VIP tickets are available, offering a meet‑and‑greet and photograph opportunity before the start of the evening.
Regular and VIP tickets can be purchased through the venue box office.
The six former players appearing at the event include Glenn Hoddle, who scored 110 goals for Spurs, and former captain Michael Dawson, who lifted the League Cup in 2008.
Gary Mabbutt, a long‑serving defender who captained the side to FA Cup victory, and was part of the squad that won the UEFA Cup in 1984, will also appear.
He will be joined by Brazilian midfielder Sandro, winger Aaron Lennon, and fellow FA Cup and UEFA Cup winner Graham Roberts.