Spurs saw the home side take the ascendency from the early stages, as Maghnes Akliouche and Ansu Fati threatened to cause havoc in a couple of early openings. Akliouche was the home side's outstanding player throughout and created countless opportunities.
Vicario would show his worth as the first half progressed, saving from Balogun three times as the goalkeeper came out on top in a tense battle with the former Arsenal striker. Coming out to thwart the United States international in a one-on-one, he then got down sharply to keep out Balogun once again just before half-time.
Other than the occasional spark from Wilson Odobert, Spurs rarely threatened - a theme which only heightened in the second period as Monaco turned the needle with a series of attacking substitutions and Thomas Frank's side struggled to react.
Takumi Minamino was off target three times when he should have scored, while Vicario was at his very best to keep out Teze. There was still time for Tottenham to create one decisive opportunity at the other end, as Pape Matar Sarr squared for fellow substitute Brennan Johnson, but the Welshman did not catch it cleanly, and his shot was blocked.