Dominic Solanke has undergone surgery on an ankle problem that has been troubling him for two months.
Solanke missed most of preseason after picking up the injury in a friendly at Reading, the first under new boss Thomas Frank.
The £65million England striker returned to make three appearances from the bench but has not started a game this season and not played for more than a month.
Initially, Spurs tried to treat it with rest and injections but this has failed to solve the issue.
'It's time to make a minor surgery,' said Spurs boss Frank ahead of Tuesday's Champions League tie at Bodo/Glimt.
'We will know more about timeframes after the international break but I don't expect it to be long.'
Randal Kolo Muani, who has missed three games with a dead leg, is not yet training and captain Cristian Romero has not travelled to Norway. Romero's absence is a precaution, according to Frank.
After Wednesday's Champions League clash in Norway, Spurs, who drew 1-1 with Wolves at the weekend, travel to Elland Road on Saturday to take on Leeds United ahead of the international break.