Tottenham suffered an injury blow in their 2-0 defeat by Crystal Palace on Sunday - just 10 days before their Europa League final clash against Manchester United.
Ange Postecoglou's side beat Bodo/Glimt 5-1 on aggregate in the semi-finals, and play in Bilbao on May 21 in search of their first European trophy since they won the UEFA Cup in 1984.
Despite their consistent bright showings in Europe this season, Spurs were once again underwhelming in the Premier League, suffering their 20th loss in the competition in 2024-25.
Goals either side of half-time by Eagles talisman Eberechi Eze meant Tottenham plummeted down to 17th place in the table after Sunday's results.
And their misfortunes on the day began early in the first half when Dejan Kulusevski was forced off just 19 minutes into the affair following a challenge by Palace captain Marc Guehi.
Kulusevski received treatment on the pitch and initially tried to play on, but exited the pitch just minutes later and was replaced by Mikey Moore.
However, after the game Postecoglou reassured Tottenham fans that their talisman's issue is not believed to be significant.
'He should be okay,' the Australian boss said. '[I was] just talking to him after. The medical team are not too concerned about him. It was just a knock.'
Tottenham are expected to be without three players for the monumental final two Wednesdays from now.
In defence, Radu Dragusin ruptured his ACL in February and has been a long-term absentee for some time.
Meanwhile, James Maddison and Lucas Bergvall are two of Spurs' midfield weapons that are set to miss the rest of the season.
The Europa League final will be played at the Estadio San Mames on May 21 - home to Athletic Bilbao - whom Man United beat to book their spot in the final.
Victory for Tottenham would spell an end to their 17-year wait for a major trophy, and a 41-year European trophy drought.
Their last trip to the top stage of a European competition was also an all-English affair, when Liverpool beat them 2-0 in the 2019 Champions League final.