Tottenham have been handed another fresh injury blow with Djed Spence missing from their squad to face Manchester City. The versatile defender played the full 90 minutes of the Champions League win over Eintracht Frankfurt, but is missing from the weekend's squad.
With it likely to be because of an injury, he is set to join Rodrigo Bentancur, Mohammed Kudus, Lucas Bergvall, Pedro Porro, Richarlison and Ben Davies as those to have suffered issues recently.
Kevin Danso is also absent for the visit of Pep Guardiola's side after he was spotted limping for much of the European tie following an early collision with Cristian Romero. Frank has since issued updates on the two players.
Speaking on the two new injury issues, Frank said: "Djed a minor calf injury. I think it's fair to say that we're hit pretty hard with injuries, but it's part of the game. We need to find solutions, others need to step up.
"Kevin Danso, having hyperextended his big toe, a ligament snapped, because he landed on the foot of an opponent, so extremely unlucky, like a random injury. He's got time with a consultant next week, so we don't know exactly the length of it."
Danso's absence has given an opportunity to Radu Dragusin with the Romanian getting minutes for the first time in over a year.
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Further forward, it looks to be a midfield pivot of Conor Gallagher and Yves Bissouma with Joao Palhinha as part of the back three again. Replacing Spence on the opposite flank to Destiny Udogie looks set to be Archie Gray.
There was some hope that Micky van de Ven would be back after missing the win in Germany, but he is still out.
Frank said on Friday: "Micky is a minor one, it will be touch and go for Sunday. We're hoping, he was on the pitch yesterday, on the pitch today. So, hopeful for that, but it's touch and go."
Wilson Odobert has dropped down to the bench with Dominic Solanke supported by Randal Kolo Muani and Xavi Simons. It could be that Frank has reverted to a back four again but given the success of the back five formation used recently, it is likely to be that again.
City arrive to Tottenham Hotspur Stadium with their own injury issues. Savinho, Jeremy Doku, Ruben Dias, Mateo Kovacic, Josko Gvardiol and John Stones are all dealing with problems.
January signings Marc Guehi and Antoine Semenyo have kept their places in the team with Rayan Cherki preferred to Phil Foden, who is on the bench, but Erling Haaland recalled after Omar Marmoush started last weekend's win over Wolves.
Frank will be concerned about the damage they can all cause but with particular focus on Semenyo considering he openly admitted Spurs tried to sign him from Bournemouth.
He said: "I can promise the Lewis family are super committed and there is no doubt the club is clear, I will break a rule, we wanted to sign Semenyo. That is a big signing with finances and all that. It is aligned and they are the quality players we’re looking for to improve the squad."
The Spurs boss later added on transfers: "The fans just want the best for the club like I do, the owners and everyone in the club. It's fair to say though that the transfer window is not like Football Manager. Maybe it would be more boring if it was with less to talk about."