Igor Tudor names Randal Kolo Muani as his striker in his first Spurs team with Palhinha in midfield. Richarlison and Dominic Solanke are on the bench.
Tottenham starting XI: Vicario, Gray, Dragusin, Van de Den, Spence, Bissouma, Palhinha, Sarr, Gallagher, Simons, Muani
Subs: Austin, Richarlison, Tel, Solanke, Souza, Oluesi, Williams-Barnett, Rowswell, Wilson
Mikel Arteta has made just two changes to the side that drew 2-2 with Wolves in midweek. Leandro Trossard comes in with Eberechi Eze starting as Arsenal's number 10.
Eze scored a hat-trick when these two played earlier in the season and the Gunners will be hoping that Eze can repeat that performance today.
Arsenal starting XI: Raya, Timber, Saliba, Gabriel, Hincapie, Zubimendi, Rice, Eze, Saka, Trossard, Gyokeres