The positive news for Thomas Frank is that striker Dominic Solanke is fit enough to return to the Tottenham bench after undergoing minor surgery to resolve an ankle injury in September.
Defender Cristian Romero misses out through suspension.
Tottenham XI: Vicario, Davies, Van de Ven, Danso, Porro, Gray, Palhinha, Tel, Simons, Odobert, Richarlison.
Subs: Dragusin, Udogie, Solanke, Spence, Kinsky, Muani, Scarlett, Byfield, Williams-Barnett.
Aston Villa boss Unai Emery will have striker Ollie Watkins and midfielder Youri Tielemans among his options on the bench.
Marco Bizot starts in goal after Emi Martinez was forced off at half-time in midweek with a calf issue.
Aston Villa XI: Bizot, Maatsen, Torres, Konsa, Cash, Kamara, Bogarde, Buendia, Rogers, McGinn, Malen.
Subs: Lindelof, Mings, Tielemans, Watkins, Digne, Garcia, Sancho, Hemmings, Wright.