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Tottenham's Xavi Simons starts a Premier League game for the first time since 8 November, while Micky van de Ven, Richarlison and Archie Gray also return to the starting line-up.
Tottenham XI: Vicario, Porro, Romero, Van de Ven, Spence, Bentancur, Gray, Kudus, Simons, Richarlison, Muani
Substitutes: Bergvall, Danso, Davies, Johnson, Kinsky, Joao Palhinha, Odobert, Sarr, Tel
Mikkel Damsgaard makes his 100th appearance for Brentford, who make four changes after the 2-0 defeat at Arsenal.
Brentford XI: Kelleher, Kaoyde, Van den Berg, Collins, Ajer, Henderson, Yarmoliuk, Schade, Damsgaard, Ouattara, Thiago
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