Tottenham boss Roberto de Zerbi has made four changes after overseeing a 1-0 loss to Sunderland in his first game in charge.
For his first home match as Spurs boss, De Zerbi hands midfielder Rodrigo Bentancur his first start since undergoing surgery on his hamstring in January.
Kevin Danso replaces the injured Cristian Romero in defence, while Yves Bissouma and Xavi Simons also come in for Archie Gray and Richarlison.
Another huge boost for Spurs is the return of James Maddison to the squad for the first time this season, after he suffered an anterior cruciate ligament injury in pre-season.
Tottenham XI: Kinsky, Porro, Danso, Van de Ven, Udogie, Bissouma, Gallagher, Bentancur, Kolo Muani, Solanke, Simons.
Subs: Austin, Dragusin, Palhinha, Richarlison, Maddison, Tel, Gray, Bergvall, Spence.
There are no changes for in-form Brighton.
Fabian Hurzeler's side have won five of their past six in the league as they make a late surge for European football, and the German names the same 11 that started in the 2-0 win over Burnley, with Danny Welbeck leading the line.
Brighton XI: Verbruggen, Wieffer, Van Hecke, Boscagli, Kadioglu, Ayari, Gross, Gomez, Hinshelwood, Minteh, Welbeck.
Subs: Steele, Igor, Rutter, Baleba, Kostoulas, Mitoma, De Cuyper, O'Riley, Veltman.