Thomas Frank makes three changes to the Tottenham side that lost 2-1 to Aston Villa in the FA Cup last weekend.
Conor Gallagher starts in midfield after completing his £35 million move from Atletico Madrid earlier this week, replacing Joao Palhinha.
Cristian Romero returns from suspension to start in defence, while Randal Kolo Muani starts in attack in place of the injured Richarlison.
Lucas Bergvall, Yves Bissouma, Destiny Udogie and Dominic Solanke return and are available off the bench.
Tottenham XI: Vicario, Porro, Romero, Van de Ven, Davies, Gray, Gallagher, Simons, Odobert, Tel, Kolo Muani.
Subs: Kinsky, Dragusin, Danso, Bissouma, Udogie, Bergvall, Solanke, Spence, Scarlett.
There are five changes for West Ham after their draining 2-1 win against Queens Park Rangers in the FA Cup.
Alphonse Areola, Ollie Scarles, Tomas Soucek, Mateus Fernandes and Pablo all come in.
West Ham XI: Areola, Todibo, Mavropanos, Wan-Bissaka, Scarles, Soucek, Fernandes, Summerville, Castellanos, Bowen, Pablo.
Subs: Hermansen, Walker-Peters, Kilman, Julio, Wilson, Rodriguez, Potts, Kante, Mayers.