Dejan Kulusevski is likely to start but manager Ange Postecoglou faces a decision over where to play the Swede, who could come in at No10 for James Maddison or replace Brennan Johnson on the right wing.
Playing Kulusevski in the front three would give Spurs more energy in the middle but he is less of a goal threat than Johnson.
Postecoglou also faces a decision at full-back, with Pedro Porro, Destiny Udogie and Djed Spence competing for two places.
Spence has gone off the boil in recent weeks, while Udogie was preferred at left-back in both legs of the quarter-final against Eintracht Frankfurt, so the Italian and Porro seem likeliest to get the nod.
Elsewhere, Postecoglou's XI should be easy to predict. Cristian Romero and Micky van de Ven will return to the backline after being rested for the chastening 5-1 defeat to Liverpool, while Lucas Bergvall and Rodrigo Bentancur have established themselves as the preferred midfield two.
Guglielmo Vicario has been shaky of late but remains Spurs' No1 goalkeeper and a dressing room leader, while Dominic Solanke will lead the line.
Radu Dragusin is Spurs' only long-term absentee with a cruciate ligament injury which will keep him out until next season, while Antonin Kinsky, Sergio Reguilon and Timo Werner are all ineligible in Europe.