Tottenham are set to be boosted by the return of Cristian Romero and Destiny Udogie against Chelsea on Saturday evening.
The pair have not played since the international break earlier this month and have been training individually to step up their recoveries.
Romero has had an adductor issue and Udogie picked up a knee injury while on Italy duty, but both are in contention to face Chelsea. Wilson Odobert is also fit and available after a side strain.
"[The] positive is that Romero, Destiny and Wilson are available for selection to the squad," Frank said at his pre-match press conference.
Frank could opt to be cautious with Udogie and give him minutes off the bench, but there is every chance Romero comes straight back into the starting lineup for such a big match.
Guglielmo Vicario will return to the starting lineup after being left out of the squad for the midweek Carabao Cup defeat to Newcastle.
Archie Gray is out with a calf injury and Dominic Solanke will not return until after the international break, as his recovery from ankle surgery remains slow.
Frank has opted for a slightly different shape in recent matches, almost with two No10s when Spurs have the ball.
Even though they have played a lot of football recently, Joao Palhinha and Rodrigo Bentancur are likely to start at the base of midfield again.
Lucas Bergvall played the role off the left wing against Newcastle, while Xavi Simons did so in the win over Everton with Mohammed Kudus as the No10.
Brennan Johnson was unconvincing in both of those matches and could drop out of the side. Richarlison has also struggled for form and Frank must be tempted to start Randal Kolo Muani up front.