Tottenham winger Wilson Odobert will undergo surgery after suffering a ruptured anterior cruciate ligament (ACL) in his left knee, his club have confirmed.
The 21-year-old Frenchman suffered the injury during the first half of his side's 2-1 home loss to Newcastle United on Tuesday.
Spurs said: "Wilson will see a specialist next week before undergoing surgery, and will then commence his rehabilitation with our medical staff."
It is the latest in a line of long-term injury problems for Tottenham, who are searching for a new manager following the sacking of Thomas Frank on Wednesday.
Spurs lost forwards Mohammed Kudus and Richarlison, midfielders Rodrigo Bentancur and Lucas Bergvall, and defender Ben Davies to significant injuries in January.
Meanwhile, playmaker James Maddison has also been out since he ruptured his ACL in August.
Tottenham signed Odobert from Burnley for a fee in the region of £25m in 2024.
He has made 33 appearances for the club this season, starting 10 Premier League games and six of the club's eight Champions League group-stage fixtures.
Spurs are 16th in the Premier League and just five points above the relegation zone following a dreadful run of form which led to Frank's dismissal after just eight months.