One win each - bragging rights up for grabs on Merseyside
Everton vs Liverpool - Saturday, kick-off 12pm, live on Sky Sports
Liverpool will be pleased to see a five-point cushion open up between themselves and the relegation spot - one they had occupied for much of the season so far. Although there are five games to go, the Reds look to have opened up a big enough gap to ensure their WSL status.
Everton too have improved under interim boss Scott Phelan, who has won three of his first four WSL matches and could become the very first manager to win four of his opening five WSL games in charge of the Toffees.
Goodison Park hasn't always been a happy home for Everton this season - although they have won the last two there in the WSL - but they will be hoping for the ultimate scalp of Liverpool this weekend.
The Toffees were big 4-1 winners at Anfield on the opening day of the season, but Liverpool had the better of their FA Cup fifth round tie a few weeks ago with a 2-1 victory.
So bragging rights are firmly up for grabs, as are three points that would surely confirm Liverpool as a WSL team next season.
Charlotte Marsh
Can anyone stop Manchester City?
Man Utd vs Man City - Saturday, kick-off 1.30pm
With an eight-point lead at the top of the WSL, it's hard to see anyone stopping Man City and their relentless pursuit of their first league title in 10 years.
But Manchester United will want to delay that - albeit briefly - with some kind of result on Saturday, if for nothing other than local bragging rights.
It will be back-to-back games at Old Trafford for them too after they also faced Bayern Munich in the Champions League at the ground on Wednesday evening - and Man City have stuttered on the road lately.
They have lost one and drawn one of their last two WSL away games and failed to score in both. Man City last went three in a row without victory away from home when losing their final three games of the 2022/23 campaign and have never failed to score in three straight in the WSL.
It's hard to see them doing so again this weekend, especially given they thrashed Tottenham 5-2 on Saturday - the fifth time they have scored five or more goals in a WSL game this season - and have had extra days of rest heading into the Manchester derby.
These games always add an extra dimension, and Man Utd will need to summon all of their derby spirit to keep Man City from another WSL win.
Charlotte Marsh
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Do you rest Little or is that too risky?
Arsenal vs Tottenham - Saturday, kick-off 5.30pm, live on Sky Sports
Kim Little is an Arsenal legend - and she's staying for a little bit longer. The Scot is an integral part to this Gunners team, which is recognised in her new contract.
Little and her industrious nature is defying logic at the age of 35. She is the only WSL player that averages over 90 per cent passing accuracy, and more than seven ball recoveries per game. She is the metronome of the team both on and off the ball.
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But do Arsenal need to manage her minutes, given the importance of the next few weeks? The Gunners have work to do to secure Champions League football for next season, but have a chance to back up last season's triumph by beating Chelsea in the quarter-finals of the same competition next week.
A two-goal lead against Chelsea is not enough, given the mentality monsters the Blues have in their squad. So even though she is a metronome, is this north London derby a good opportunity for Little to rest and recharge? Or is that too big a risk, given her importance?
Sam Blitz
Chelsea need a big boost against Aston Villa
Chelsea vs Aston Villa - Sunday, kick-off 12pm, live on Sky Sports
Sunday's match against Aston Villa comes at a critical moment in Chelsea's season.
They are in the middle of two games against Arsenal in the Champions League - losing the first leg 3-1 on Tuesday - and after a 1-1 draw against London City last weekend, they lost ground in the race to compete in Europe next season.
The Blues need a big performance and a big result on their return to Kingsmeadow to not only boost their confidence ahead of Wednesday's second leg, but also keep pace with the teams around them in the top four.
The remainder all play on Saturday, and Chelsea could be out of the European places by the end of the evening.
Aston Villa won't make it easy though, and have enjoyed games on the road recently. They have won more points in the league under Natalia Arroyo away (20) than at home (15), and have conceded just one goal in their last two away games.
Ultimately though, these are the games Chelsea should and expect to win, and it's vital that they do this weekend.
Charlotte Marsh
Could relegation battle go down to goal difference?
West Ham vs London City Lionesses - Sunday, kick-off 12pm, live on Sky Sports
The last time these two met, London City Lionesses profited on a howler from goalkeeper Kinga Szemik to earn a 1-0 win. It was a result that confirmed West Ham would be relegation candidates, and that London City weren't.
West Ham were winless then but their position now is slightly better. Rita Guarino has steadied the ship somewhat, but their position remains perilous.
The relegation battle, which this year sees bottom spot undergo a relegation play-off, could come down to goal difference. Leicester and West Ham are neck-and-neck on -26 and -25 respectively, with three points separating the two.
West Ham's 5-0 loss to Arsenal last time out referenced the necessity to not just get points, but if you lose - you have to lose 'well'. The last time the Hammers lost by that margin, it was to Chelsea in January and that sparked a mini-revival in terms of wins and points.
Guarino will be hoping that history repeats itself - not the reverse fixture against London City.
Sam Blitz
Leicester looking to right some wrongs against Brighton
Leicester vs Brighton - Sunday, kick-off 12pm, live on Sky Sports
Leicester will be looking to bounce back from a 2-1 home defeat to Aston Villa last weekend when they take on Brighton as the relegation play-off looms.
The Foxes currently sit bottom of the WSL, three points behind West Ham with five games remaining and could face the challenge of playing either Birmingham City, Crystal Palace, Newcastle United or Bristol City in a play-off.
In their last five matches, Rick Passmoor's side have managed to score just two goals, while conceding 14.
It follows a more concerning trend for the Foxes, who have only scored nine goals this season - the lowest in the league - and conceded 35.
Leicester will be looking to right some wrongs after the Foxes' last meeting with Brighton back in November, where they lost that game 4-1, with Shannon O'Brien scoring their consolation that day.