The Lancashire-based official has been handed the middle for the home game with Tottenham Hotspur.
His video assistant will be Neil Davies.
Kavanagh has already refereed eight games this season, including Europa League fixtures and the Community Shield at Wembley.
He was at the centre of debate in the latter for failure to award Crystal Palace a penalty for handball by Alexis Mac Allister.
Kavanagh averaged five yellow cards per game across last season so is comfortably below that figure so far this term.
He was in the news last season when he showed Declan Rice a second yellow card as Albion drew 1-1 at Arsenal.
That decision as Joel Veltman looked to take a quick free-kick, and the fact he did not show Joao Pedro yellow earlier in the game, were the subject of much complaint from Arsenal’s fans and sympathisers in the media.
His domestic season ended with the Championship play-off final between Sheffield United and Sunderland – so a good memory for current Albion winger Tommy Watson.
The full officiating line-up for Albion v Tottenham is as follows.
Referee: Chris Kavanagh. Assistants: Dan Cook, Ian Hussin. Fourth official: Tom Nield. VAR: Neil Davies. Assistant VAR: Rob Jones.