Roberto De Zerbi has made six changes to the team that started our last match before the international break against Aston Villa as Archie Gray, Marcos Senesi, Destiny Udogie, Conor Gallagher, Lucas Bergvall and Mohammed Kudus come in for Pedro Porro, Micky van de Ven, Andy Robertson, Rodrigo Bentancur, Mateus Fernandes and Omar Marmoush.
Attacker Kudus starts a league game for the first time since his return from injury while striker Dominic Solanke captains the team for the first time.
Here’s our line-up in full...
Starting XI: Kinsky, Senesi, van Hecke, Gallagher, Udogie, Gray, Bergvall, Tonali, Savio, Solanke (c), Kudus.
Substitutes: Dubravka, Tosin, van de Ven, Davies, Bentancur, M Fernandes, Maddison, Tel, Marmoush.
Hosts Manchester United line up as follows...
Starting XI: Lammens, Maguire, Lisandro Martinez, Bruno Fernandes (c), Cunha, Yoro, Amad Diallo, Tielemans, Mbeuma, Shaw, Mainoo.
Substitutes: Darlow, Dalot, Mount, Rashford, Zirkzee, Andrey Santos, Baleba, Heaven, Lacey.