Tottenham Hotspur have one game left to ensure they avoid a disastrous relegation to the Championship and a league fixture against Lincoln City next season.
Tottenham knew they could have wrapped the Premier League survival battle up with a point against Chelsea at Stamford Bridge on Tuesday night, but a 2-1 defeat means that the fight with West Ham United to stay in the top flight will go down to the final day on Sunday.
Spurs are still in a strong position, knowing that a point against Everton at the Tottenham Hotspur Stadium will be enough to see the seal their spot in the Premier League next season.
The north Londoners also know their neighbours from the capital have to beat Leeds United at the London Stadium at the same time, but Nuno Espirito Santo's men have hit poor form at the wrong time.
The Irons have now lost three successive Premier League matches with the latest coming against Newcastle United on Sunday, and they now face an in-form Leeds team who are unbeaten in their last eight top tier games.
The display at Stamford Bridge was below-par compared to some we have seen from De Zerbi's side recently, and he has some big decisions to make ahead of the visit of David Moyes' men.
Randal Kolo Muani Disappoints Again for Tottenham
Tottenham disappointed on a night when they had the chance to prevent the relegation battle going to the final day, and like he has on many occasions in the Premier League this season, Kolo Muani was their most disappointing performer.
The France international was awarded a 3/10 rating by Alasdair Gold for his performance, before he was replaced by James Maddison in the 69th minute.
Because of injuries, De Zerbi doesn't have a lot of options to change his attack, but given Kolo Muani was a passenger again, and has a record of one goal and one assist in 29 Premier League appearances this term, now could be the time to drop him.
De Zerbi Needs to Drop Joao Palhinha Too vs Everton
Joao Palhinha was only used from the substitutes' bench in De Zerbi's opening three Premier League matches in charge, but it was his crucial winning goal at Wolves that has seen him start the next three games under the Italian.
While the Portugal international has the experience and leadership to make a difference in this Tottenham team, he has struggled with the demands of De Zerbi-ball at times, none more so than against Chelsea.
He failed to close down Enzo Fernandez quick enough from his long-range goal, while his hesitancy in possession isn't suited to De Zerbi's wish to pass the ball quickly.
Palhinha was replaced by Pape Matar Sarr at the same time Kolo Muani was withdrawn, and neither player should be in the starting XI against the Toffees this weekend.
De Zerbi does love Palhinha and has said he would '100%' sign him on a permanent deal from Bayern Munich this summer, but separate reports from Portugal in recent days have suggested the player is keen to move to his homeland and is in advanced talks to join Sporting Lisbon.
With no guarantee the 30-year-old is a Spurs player next season, De Zerbi should select someone like Sarr, Bissouma or Archie Gray ahead of him against Moyes' men.