Frank remains under pressure and a group of Spurs fans have organised a walkout in the 75th minute.
Spurs are in danger of being dragged into a relegation battle after a poor run of form in the Premier League but will hope to build on their midweek Champions League win against Eintracht Frankfurt.
City need to respond to Arsenal’s win at Leeds on Saturday, a result that leaves Pep Guardiola’s side seven points behind the leaders.
Guardiola does not have a good record against Spurs but knows his side cannot afford many slip-ups in the title race.
TV channel: In the UK, the game will be televised live on Sky Sports Premier League and Main Event.
Coverage on Sky Sports Premier League will begin at 4pm ahead of a 4.30pm kick-off, while coverage on Main Event will go live at 4.25pm.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Sam Tabuteau at the ground.