Pep Guardiola has lost Jeremy Doku to a calf injury and has gone with Cherki and Antoine Semenyo in attack either side of Erling Haaland.
Semenyo and fellow new signing Marc Guehi are back in the team after being ineligible in Europe on Wednesday.
Rodri was missing against Galatasaray due to suspension but also returns at the Tottenham Hotspur Stadium in place of Omar Marmoush, as City bid to respond to Arsenal’s win at Leeds on Saturday.
Haaland dropped to the bench in last weekend’s win over Wolves but started and scored in the Galatasaray win and starts.
Ruben Dias is closing in on a return but is not yet ready to make his comeback so Abdukodir Khusanov is alongside Guehi at centre-back.
On Doku’s injury, Guardiola’s assistant Pep Lijnders said on Friday: “Its similar to last injury. Only that time it was lateral, this one is on the centre. It was 18 days. I think this time it will be a little bit shorter as he’s a robust player.”