Thomas Frank was sacked on Wednesday morning after a home defeat by Newcastle.
At about the same time, De Zerbi parted company with Marseille after Champions League elimination and two poor domestic results in Paris.
But his stock is high in England with many fans and observers recalling the best of his time in charge of the Seagulls.
Spurs’ defeat ensured they remained below Albion in the table.
Fabian Hurzeler’s men remain 14th ahead of their game at Aston Villa.
Betfair are quoting De Zerbi at 8/11 with current USA and ex-Spurs chief Mauricio Pochettino at 14/1.
Fulham’s Marco Silva is 5/1 and Bournemouth’s Andoni Iraola 6/1.
Ruben Amorim, recently sacked by Manchester United, is priced at 15/2 and ex-Tottenham striker Robbie Keane, now in charge of Ferencvaros, 9/1.
Oliver Glasner, whose tenure at Crystal Palace is coming to an end, is 14/1.
There were claims in recent weeks that Hurzeler would be the leading candidate if Frank were to be axed.
But that appeared fanciful at the time – and even more so now.
The latest tumultuous result of Frank’s dismal reign resulted in Spurs falling to 16th in the Premier League and made it two wins in 17 league fixtures.
Not for the first time in 2026 Frank faced calls to be “sacked in the morning” by disgruntled Tottenham fans and there were also chants for old boss Mauricio Pochettino during the club’s eighth home loss in all competitions this season.
With 12 days until Spurs host rivals Arsenal on February 22, it left chief executive Vinai Venkatesham, sporting director Johan Lange and the Lewis family, which runs the club’s major shareholder ENIC, with a decision to make over Frank’s future and they have dismissed the 52-year-old.
Marseille crashed out of Europe after 3-0 defeats by Liverpool and Club Brugge, which left them vulnerable to a lasp-gasp goal by Benfica to knock them out.
Anatolij Trubin, the Benfica goalkeeper who played for De Zerbi at Shakhtar, headed the goal which eliminated OM.
They then let slip a 2-0 lead to draw 2-2 at lowly Paris FC before losing 5-0 to PSG, leaving De Zerbi's position at Stade Velodrome untenable.
Albion's game at Spurs is currently listed for April 18.