Dejan Kulusevski is back training with the first team after a long knee lay-off. Roberto De Zerbi called his recovery 'inspirational' and said Spurs must react and take responsibility.
Tottenham are set to block any January move for Dominic Solanke despite his poor form, with Spurs short of attacking depth and Richarlison's future still in doubt.
Tottenham have stepped up interest in Espanyol striker Roberto Fernandez, who has scored 6 goals in 7 La Liga games, as Spurs look for a reliable January goalscorer.
Alan Shearer warned Roberto De Zerbi needs results soon and said a limp 2-0 or 3-0 defeat at Manchester United would turn up the heat despite signs of improvement at Spurs.
Chris Sutton backed Manchester United to beat Spurs 2-1, arguing Tottenham lack the match-winner Bruno Fernandes offers and have missed decisive attacking quality since Harry Kane and Son Heung-min.
Tottenham are scouting Benfica striker Vangelis Pavlidis after his prolific start. A January move looks difficult, with Benfica keen to keep him and a €100m release clause in place.
Dejan Kulusevski played his first 11-a-side training game after more than 500 days out, a key recovery milestone, though Spurs have set no date for a competitive return.
Roberto De Zerbi urged Spurs to 'react' at Manchester United after the 3-2 defeat by Aston Villa. Bottom of the table, Tottenham need goals, sharper finishing and a first league win.
Micky van de Ven and Jan Paul van Hecke are available for Manchester United after injury scares. James Maddison could return, Pedro Porro remains out, and Dejan Kulusevski stepped up his rehabilitation.
Roberto De Zerbi said Dejan Kulusevski will travel with the Spurs squad to Manchester United after returning to scrimmages, with his recovery now being assessed week by week.
Paul Robinson said Spurs must play to their strengths at Manchester United - press high, stay on the front foot and attack with conviction - to turn promise into a result.
Tottenham are interested in a January loan for Real Madrid forward Endrick, who has played only 4 La Liga minutes this season after a productive spell at Lyon.