The game is close to a sell-out with Spurs in town for the first time since 2013, many hoping to catch a first glimpse of the Europa League champions under Dane Frank.
Spending seven years in charge at Brentford- as well as having two years on the coaching staff- before making the move across London, Frank is no stranger to the SCL Stadium.
Almost 17,000 were in attendance for his first trip to Berkshire in the hot seat, the Royals prevailing 2-1 over the Bees to all-but ensure survival in the second tier.
On route to finishing third in 2019/20, the West London side completed the double over Reading, winning 3-0 on the road, before losing to Fulham in the play-off final.
Promotion would follow, however, in 2020/21, and again Brentford would complete the double over promotion-chasing Reading.
A 3-1 victory at the SCL Stadium ended a run of seven matches unbeaten for Veljko Paunovic's side, this coming despite Lucas Joao giving the hosts as deserved lead.
Goals from Ivan Toney and Jay Dasilva turned the tie on its head and put the visitors clear at the top of the table.
Come May, Reading would sit seventh despite being in the top six for the entirety of the season. Brentford would be victors under the Wembley arch, beating Swansea City to reach the Premier League, where they remain to this day.
The Royals record against Frank on the road is even less impressive, losing both trips and the last four meetings overall.
Frank will be looking to extend his unbeaten run in Berkshire on Saturday but more importantly, start putting the building blocks in place to successfully replace the popular Ange Postecoglou.
Reading-born Dominic Solanke could feature, a regular goal-scorer over the Royals down the years with Bournemouth.
The England international grew up in the town but rose through the Chelsea ranks and has become a full England international.