Thomas Frank's first Premier League game in charge of Tottenham Hotspur will be at home against promoted Burnley on August 16.
But the Dane faces a daunting first away game as Spurs go to Manchester City the following weekend on August 23.
After a home fixture against Bournemouth on August 30, the next game will be Frank's first London derby in charge as Tottenham visit West Ham on September 13.
In full: All the 2025/26 Premier League fixtures
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Spurs face a difficult November as they host London rivals Chelsea at the start of the month, followed by a home game against Manchester United on November 8, which comes after a Champions League midweek.
Then, after the international break, Frank takes charge of his first north London derby as Tottenham take on Arsenal at the Emirates Stadium on November 22.
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The return north London derby at the Tottenham Hotspur Stadium is on February 21, which comes at the end of a tough run of fixtures as Spurs face Manchester City (January 31), Manchester United (February 7), Newcastle (February 11) and then the Gunners.
Tottenham's penultimate Premier League match of the season is at London rivals Chelsea on May 17, before finishing the campaign against Everton at home on May 24.
Tottenham's 2025/26 Premier League fixtures
All fixtures subject to change.
August
September
October
November
December
January
February
March
April
May
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From next season, Sky Sports' Premier League coverage will increase from 128 matches to at least 215 games exclusively live.
And 80 per cent of all televised Premier League games next season are on Sky Sports.