Spurs have already had plenty of injury problems to worry about this season.
Tottenham had 16 players on international duty in October as the World Cup qualifying campaign is slowly coming to a close.
Thomas Frank will have been praying for each player to return to N17 fully fit as Tottenham look to continue their promising start to the Premier League season.
However, Yves Bissouma suffered another shock injury on Sunday and recently took to Instagram to post an update about his current state.
Yves Bissouma suffers injury during Mali vs Madagascar
Bissouma is yet to feature for Spurs in 2025-26 after suffering a serious knee injury in August; however, he just regained full fitness in time for the international break.
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Bissouma was close to leaving Spurs in the summer transfer window, yet the knee injury he previously sustained prevented him from leaving.
During Mali’s 4-1 win over Madagascar, Bissouma was stretchered off in the closing moments of the match after feeling the force of a challenge on his ankle, only minutes after coming on.
He sent a message to Tottenham fans on Tuesday detailing how he felt, whilst also showing images of him on crutches with a protective brace around his ankle.
He said: “Zero regrets. I once again thoroughly enjoyed representing my country, and if I had to do it all over again, I would do it for the love of my country.
“I fell, but I will know how to get back up. Every challenge is a lesson, every fall a reminder of my faith and my strength.
“This is not the end, just the beginning of a new chapter, stronger, more determined. See you soon…”
Whilst the extent of the injury is unclear, the severity of the message suggests Bissouma could be set for yet another lengthy spell on the sidelines.
Yves Bissouma may never play for Spurs again
Bissouma is already out of favour with Frank, yet this setback could have bigger ramifications for his future at Tottenham.
Disciplinary issues have been a problem for the 29-year-old, and this has been something that Frank has not tolerated at all.
Bissouma was left out of the UEFA Super Cup final squad against Paris Saint-Germain, and this new injury could spell even more trouble for him.
The midfielder has already been susceptible to injury woes in the past at Tottenham, yet under Ange Postecoglou last season, he was a crucial part of the team that went on to win the Europa League.
With Joao Palhinha and Pape Matar Sarr flourishing under Frank, the future continues to look bleak for Bissouma.