Third-bottom West Ham make the short journey to Spurs, who have lost 15 of their past 28 domestic home games in all competitions and only won 25% of those fixtures.
This will be West Ham boss Nuno Espirito Santo's third successive league match against a side he has previously managed, following defeats by Wolves and Nottingham Forest.
Recent negative headlines have increased the pressure on head coach Thomas Frank, who unwittingly drank from an Arsenal-branded cup prior to the league defeat at Bournemouth and then suffered an FA Cup exit at home to Aston Villa.
A chorus of boos - aimed at both Frank and the players - have provided the soundtrack to a troubled time. Tottenham have won just two of their past 12 league games to sit 14th and are out of both domestic cups.
The arrival of industrious midfielder Conor Gallagher is unlikely to remedy the team's well-documented lack of attacking creativity. That has led to them being reliant on corners as a source of goals, scoring 11 times from such situations. It is the joint-highest tally in the division and, at 36.7%, by far the biggest percentage of any team's overall tally.
Spurs will doubtless be targeting West Ham's defensive frailties from set-pieces; they have conceded a league-high 12 goals from corners this season.
West Ham enjoyed a first victory in 64 days last weekend, beating QPR in the FA Cup third round thanks to a first goal for the club from £26m new signing Valentin 'Taty' Castellanos.
Nonetheless, a 10-match winless run in the league has yielded just four points and left them seven points from safety. It is their longest wait for a top-flight triumph since 2006-07, when they lost 4-3 to Spurs at the end of an 11-game streak. The Hammers are also yet to keep a clean sheet in 17 matches since Nuno's arrival in September.
Nuno praised his side's "fight and desire" last weekend but their dismal recent record in Premier League derbies suggests they have not shown those qualities often enough.
West Ham have lost all six of their Premier League fixtures against London opposition this season. Only two sides in top-flight history have endured longer runs; QPR's seven straight defeats in 1995-96 and a 13-match losing run for Fulham from August 2018 to November 2020.