Tottenham were defeated at the weekend by Enzo Maresca's Chelsea, losing out on home turf to their close rival by a goal to nil.
Joao Pedro's first-half strike proved the difference at the Tottenham Hotspur Stadium as Frank's side recorded their second loss in the space of a week.
Spurs had travelled to the north-east days earlier where they faced Newcastle United in the Carabao Cup Fourth Round, a game in which the Magpies eliminated Frank and his team.
Thomas Frank reacts to viral Djed Spence and Micky van de Ven moment for Spurs
Chelsea's visit to North London gave Spurs the opportunity to get back to winning ways against a local rival, however, that did not transpire as the Blues returned to the west of the city with all three points.
At full-time, defenders Micky van de Ven and Djed Spence were caught on camera expressing their discontent at the outcome of the match as they approached head coach Frank.
The Spurs pair walked past the Tottenham boss, despite Frank's attempts to console them.
The Dane has since revealed that both players paid a visit to his office the day after the game in order to apologise for having seemingly blanked their manager.
"Micky and Djed came into my office yesterday unprompted to say sorry. They were just frustrated," Frank said on Monday.
"Of course I was happy they came in because I knew the questions would come today. We had a good chat but we will keep it internally. It would be very, very, very unusual for me to throw a player under the bus, because we're all human," he added.
Spurs face FC Kobenhavn in the Champions League on Tuesday evening and are strong favourites for the match.
Whether Spence and Van de Ven have a part to play remains to be seen, but it appears Frank bears no ill will towards the pair.