Tottenham travel to Monaco on Wednesday looking to bounce back from defeat last time out.
Tottenham fell to a 2-1 loss to Aston Villa on 19 October, with Emi Buendia’s strike in the 77th minute proving the difference.
Thomas Frank will be looking to get a reaction from his players as Spurs return to Champions League action.
Cristian Romero went off before Tottenham’s loss to Villa, and he joins a long injury list containing the likes of Destiny Udogie, Dejan Kulusevski and Dominic Solanke.
Xavi Simons and Mathys Tel dropped for Monaco vs Tottenham
Xavi Simons has had a poor start to his Tottenham career so far, and that continued in the defeat on Sunday.
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Simons was utilised in an attacking midfield role, but he failed to make things happen, with just one chance created and just three passes into the final third, as per Sofascore.
He also struggled defensively, with just one interception and won just five ground duels out of the 12 that he attempted, for a 42 per cent success rate.
He is expected to be replaced by Lucas Bergvall in the number 10 role in the starting line-up for the clash with the Ligue 1 outfit.
Meanwhile, Randal Kolo Muani is predicted be called upon to lead the line, after Mathys Tel struggled against Unai Emery’s side, with Mohammed Kudus and Wilson Odobert on the flanks.
The Frenchman did not create a single chance, and missed the only big chance that he had, while taking just 15 touches in the contest in 60 minutes on the pitch.
The final change is predicted to be Pape Sarr partnering Joao Palhinha, rather than Rodrigo Bentancur in the centre of the park, the midfielder was one of Spurs’ best performers in the loss, but he needs to be kept fit for the run of games coming up.
The Uruguayan scored the opener, created one chance, made three recoveries and won three of his four ground duels, for a 75 per cent success rate, emphasising his importance to Frank’s team.
The rest of the team is expected to be unchanged, with the backline of Guglielmo Vicario, Pedro Porro, Kevin Danso, Micky Van de Ven and Djed Spence keeping their places in the side.
Frank needs to bench Simons, he needs to earn his place
Simons was a high-profile signing when he came through the doors, and he was expected to take over from James Maddison, after the English star was ruled out for up to seven months.
However, he has failed to do so, with just one assist in eight appearances since he moved to North London from RB Leipzig.
The Lilywhites need Simons to earn his place, through regular contributions from the bench, before he is promoted back into the team.
Given that he joined for a fee of around £52million, he should be making an instant impact, but so far, that has not happened.
He may just need a run out of the side, before he comes back with a vengeance.