Micky van de Ven and Pedro Porro will both return to the Tottenham squad against Charlton, while new signing Savio could make his debut.
Nottingham Forest have responded to Tottenham interest in one of their best players, while Savio has officially completed his big-money move from Manchester City.
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The Spurs playmaker had limited involvement during pre-season, with De Zerbi eager not to rush his comeback after he missed most of last season following surgery on a ruptured anterior cruciate ligament sustained in the summer.
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