Callum Wilson scored a dramatic late winner for West Ham against Everton to keep the Hammers out of the drop zone after Tottenham Hotspur thought they had clawed their way out.
The Hammers took the lead through Tomas Soucek, opening up the scoring just after half-time.
Tottenham's injury woes have intensified with Destiny Udogie now facing a fitness concern before Saturday's vital trip to Molineux.
The 23-year-old Italian defender has battled multiple physical setbacks throughout the campaign, including issues with his knee and hamstring.
Tottenham have posted a job advertisement on LinkedIn seeking a Men's First Team Lead Psychologist, just weeks after manager Roberto De Zerbi highlighted mental fragility within the squad.
The north London club, currently battling against Premier League relegation, published the vacancy on Tuesday as they look to strengthen their backroom staff.
Tottenham star Kevin Danso has broken his silence after being the subject of "abhorrent" racist abuse.
The Spurs defender received a series of racial comments following Tottenham's 2-2 draw against Brighton.
Les Ferdinand has criticised Tottenham star Xavi Simons for his enthusiastic goal celebration after the club drew 2-2 with Brighton on Saturday night.
After earlier efforts from Pedro Porro and Kaoru Mitoma, Simons netted a splendid strike with just 13 minutes left on the clock.
Brighton midfielder Diego Gomez was left in tears during Saturday's fixture against Tottenham after sustaining what appeared to be a serious injury early in the contest.
The 23-year-old came down awkwardly on his left leg following an aerial challenge with Spurs defender Destiny Udogie, leaving him writhing in agony on the turf.
Tottenham Hotspur captain Cristian Romero has been ruled out for the remainder of the campaign after suffering a partial tear to his medial cruciate ligament during Sunday's 1-0 loss at Sunderland.
The 27-year-old Argentine sustained the injury in an unfortunate collision with his goalkeeper, Antonin Kinsky, at the Stadium of Light.
Roberto de Zerbi's tenure at Tottenham Hotspur has begun in the worst possible fashion, with the Italian suffering a 1-0 loss at Sunderland that leaves the north London club firmly entrenched in the Premier League's bottom three.
The defeat at the Stadium of Light means Spurs remain two points adrift of West Ham United, who secured a comfortable 4-0 victory over Wolverhampton Wanderers on Friday evening.
Tottenham have reportedly reached a verbal agreement to bring Andy Robertson to north London on a free transfer this summer.
The deal is understood to be subject to Spurs remaining in the Premier League.
West Ham delivered a commanding performance at the London Stadium this evening, demolishing Wolves 4-0 in a result that transforms the Premier League's relegation battle.
The Hammers climbed out of the drop zone with this emphatic triumph, moving two points clear of danger.